Seeking refuge from his former life as the Mexican president s bodyguard Lucas Machete Cano finds himself in a no-name town, surrounded by even more trouble than before. Machete makes enemies out of a band of human traffickers as their leader tries to have his way with one of the local girls. Things get worse when Machete crosses paths with a man from his past, who is ready to capture Machete, dead or alive, for the CIA. Haunted by demons from his past, Machete s only choice is to take down his enemies and, with help from his guardian angel Panchito, finish what he started.